Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

S Janssen, K Osbak, R Holman, S Hermans… - Infection, 2017 - Springer
S Janssen, K Osbak, R Holman, S Hermans, A Moekotte, M Knap, E Rossatanga…
Infection, 2017Springer
There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the
Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral
therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in
five. All IRIS cases were mucocutaneous manifestations. There were no cases of
tuberculosis (TB) IRIS, but active TB (n= 20) was associated with developing other forms of
IRIS (p= 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild …
Abstract
There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.
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